Focal adhesions: What's new inside
نویسندگان
چکیده
منابع مشابه
Focal adhesions: what's new inside.
The cytoplasmic side of focal adhesions is comprised of large molecular complexes that link transmembrane receptors, such as integrins, to the actin cytoskeleton and mediate signals modulating cell attachment, migration, proliferation, differentiation, and gene expression. These complexes are heterogeneous and dynamic structures that are apparent targets of regulatory signals that control the f...
متن کاملFocal adhesions
What are they? Focal adhesions are the anchor points of the cell. These dynamic cytoskeletal structures are regions where the cell membrane firmly attaches to the extracellular matrix or the substratum. At the same time, focal adhesions provide scaffolding; they associate with an elaborate actin network inside the cell. Importantly, it’s now known that focal adhesions also act as communication ...
متن کاملMechanotransduction and focal adhesions.
Cellular FAs (focal adhesions) respond to internal and external mechanical stresses which make them prime candidates for mechanotransduction. Recent observations showed that the FA proteins including vinculin, FAK (FA kinase) and p130Cas are crucial for the ability of cells to transmit forces and to generate cytoskeletal tension. When mechanically stimulated, cells respond by modulating the spr...
متن کاملFocal adhesions come unstuck
Focal adhesions come unstuck C rawling cells pick up after themselves before moving on. Ezratty et al. (1) show that cells use the endocytic protein clathrin to reabsorb the integrin receptors that attach them to surfaces, instead of simply leaving the molecules behind. Cells on the go gain traction by forming focal adhesions (FAs), temporary attachments to the surface. But if they can't break ...
متن کاملPaxillin: a new vinculin-binding protein present in focal adhesions
The 68-kD protein (paxillin) is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers in chicken embryo fibroblasts. It is also present in the focal adhesions of Madin-Darby bovine kidney (MDBK) epithelial cells but is absent, like talin, from the cell-cell adherens junctions of these cells. Paxillin purified from chicken gizzard smooth muscle migrate...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2006
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2006.03.029